According to Nye and Brice (2005), “The use of mega-vitamin intervention began in the early 1950s with the treatment of schizophrenic patients.”
Since then dietary supplements, including various formulations of multi-vitamin/mineral supplements, have been developed for a wide range of different groups including children, men, women, pregnant women and older people.
According to Adams et al (2011) dietary supplements are in widespread use as an intervention for autistic people.
“According to a recent survey of 539 physicians, vitamin/mineral supplements are among the most widely recommended medical interventions for autism, and are recommended by 49% of physicians for children with autism”.