Risperidone and Autism Ranking:

Studies and Trials

This section provides details of scientific studies into the effectiveness of risperidone for people with autism which have been published in English-language, peer-reviewed journals.

If you know of any other publications we should list on this page please email info@informationautism.org

Please note that we are unable to supply publications unless we are listed as the publisher. However, if you are a UK resident you may be able to obtain them from your local public library, your college library or direct from the publisher.

Related Studies and Trials

• Alexander R., Michael D., Ganghadaran S. (2004) The use of risperidone in adults with Asperger syndrome. British Journal of Learning Disabilities. 50(99), Read Abstract (New Window)
  
  
• Aman M. G. et al. (2008) Cognitive effects of risperidone in children with autism and irritable behavior. Journal of Child and Adolescent Psychopharmacology. 18(3), Read Abstract (New Window) Read Full (New Window)
  
  
• Aman M. G. et al. (2005) Acute and long-term safety and tolerability of risperidone in children with autism. Journal of Child and Adolescent Psychopharmacology. 15(6), Read Abstract (New Window)
  
  
• Aman M. G. et al. (2009) Medication and parent training in children with pervasive developmental disorders and serious behavior problems: Results from a randomized clinical trial. Journal of the American Academy of Child and Adolescent Psychiatry. 48(12), Read Abstract (New Window) Read Full (New Window)
  
  
• Aman M. G. et al. (2015) Tolerability, safety, and benefits of risperidone in children and adolescents with autism: 21-month follow-up after 8-week placebo-controlled trial. Journal of Child and Adolescent Psychopharmacology. 25(6), Read Abstract (New Window) Read Full (New Window)
  
  
• Arnold L. E. et al. (2003) Parent-defined target symptoms respond to risperidone in RUPP autism study: customer approach to clinical trials. Journal of the American Academy of Child and Adolescent Psychiatry. 42(12), Read Abstract (New Window)
  
  
• Arnold L. E. et al. (2012) Research Units of Pediatric Psychopharmacology (RUPP) Autism Network randomized clinical trial of parent training and medication: One-year follow-up. Journal of the American Academy of Child and Adolescent Psychiatry. 51(11), Read Abstract (New Window) Read Full (New Window)
  
  
• Boon-Yasidhi V. et al. (2002) Risperidone in the treatment of autistic Thai children under 4 years of age. Journal of the Medical Association of Thailand. 85 Read Abstract (New Window)
  
  
• Canitano R. (2006) Self injurious behavior in autism: clinical aspects and treatment with risperidone. Journal of Neural Transmission. 113(3), Read Abstract (New Window)
  
  
• Capone G. et al. (2008) Risperidone use in children with Down syndrome, severe intellectual disability, and comorbid autistic spectrum disorders: A naturalistic study. Journal of Developmental and Behavioral Pediatrics. 29(2), Read Abstract (New Window)
  
  
• Diler R. S., Firat S., Avci A. (2002) An open-label trial of risperidone in children with autism. Current Therapeutic Research. 63(1), Read Abstract (New Window)
  
  
• Farmer C. A. et al. (2012) Predictors and moderators of parent training efficacy in a sample of children with autism spectrum disorders and serious behavioral problems. Journal of Autism and Developmental Disorders. 4(6), Read Abstract (New Window)
  
  
• Fayyazi A. et al. (2014) A comparison of risperidone and buspirone for treatment of behavior disorders in children with phenylketonuria. Iranian Journal of Child Neurology. 8(4), Read Abstract (New Window) Read Full (New Window)
  
  
• Findling R. L., Maxwell K., Wiznitzer M. (1997) An open clinical trial of risperidone monotherapy in young children with autistic disorder. Psychopharmacology Bulletin. 33(1), Read Abstract (New Window)
  
  
• Fisman S., Steele M. (1996) Use of risperidone in pervasive developmental disorders: a case series. Journal of Child and Adolescent Psychopharmacology. 6(3), Read Abstract (New Window)
  
  
• Gagliano A. et al. (2004) Risperidone treatment of children with autistic disorder: effectiveness, tolerability, and pharmacokinetic implications. Journal of Child and Adolescent Psychopharmacology. 14(1), Read Abstract (New Window)
  
  
• Gencer O. et al. (2008) Comparison of long-term efficacy and safety of risperidone and haloperidol in children and adolescents with autistic disorder : An open label maintenance study. European Child and Adolescent Psychiatry. 17(4), Read Abstract (New Window)
  
  
• Ghaeli . P. et al. (2014) Effects of risperidone on core symptoms of autistic disorder based on childhood autism rating scale: an open label study. Indian Journal of Psychological Medicine. 36(1), Read Abstract (New Window) Read Full (New Window)
  
  
• Ghanizadeh A., Sahraeizadeh A., Berk M. (2014) A head-to-head comparison of aripiprazole and risperidone for safety and treating autistic disorders, a randomized double blind clinical trial. Child Psychiatry and Human Development. 45(2), Read Abstract (New Window)
  
  
• Hellings J. A. et al. (2001) Weight gain in a controlled study of risperidone in children, adolescents and adults with mental retardation and autism. Journal of Child and Adolescent Psychopharmacology. 11(3), Read Abstract (New Window)
  
  
• Hellings J. A. et al. (2006) A crossover study of risperidone in children, adolescents and adults with mental retardation. Journal of Autism and Developmental Disorders. 36(3), Read Abstract (New Window)
  
  
• Horrigan J., Barnhill L. (1997) Risperidone and explosive aggressive autism. Journal of Autism and Developmental Disorders. 27(3), Read Abstract (New Window)
  
  
• Hughes D. M., Libretto S. E., Cunningham M. M. (2002) Risperidone in children and adolescents with autistic disorder and aggressive behaviour. British Journal of Developmental Disabilities. 48(95), Read Abstract (New Window)
  
  
• Kent J. M. et al. (2013) Risperidone dosing in children and adolescents with autistic disorder: A double-blind, placebo-controlled study. Journal of Autism and Developmental Disorders. 43(8), Read Abstract (New Window)
  
  
• Kent J. M. et al. (2013) An open-label extension study of the safety and efficacy of risperidone in children and adolescents with autistic disorder. Journal of Child and Adolescent Psychopharmacology. 23(10), Read Abstract (New Window)
  
  
• King B. et al. (2003) Use of risperidone in a paediatric population: an observational study. Journal of Paediatrics and Child Health. 39(7), Read Abstract (New Window)
  
  
• Lamberti M. et al. (2016) Head-to-head comparison of aripiprazole and risperidone in the treatment of ADHD symptoms in children with autistic spectrum disorder and ADHD: A pilot, open-label, randomized controlled study. Pediatric Drugs. 18(4), Read Abstract (New Window)
  
  
• Lemmon M. E., Gregas M., Jeste S. S. (2011) Risperidone use in autism spectrum disorders: A retrospective review of a clinic-referred patient population. Journal of Child Neurology. 26(4), Read Abstract (New Window)
  
  
• Luby J. et al. (2006) Risperidone in preschool children with autistic spectrum disorders: an investigation of safety and efficacy. Journal of Child and Adolescent Psychopharmacology. 16(5), Read Abstract (New Window)
  
  
• Malone R. P. et al. (2002) Risperidone treatment in children and adolescents with autism: short- and long-term safety and effectiveness. Journal of the American Academy of Child and Adolescent Psychiatry. 41(2), Read Abstract (New Window)
  
  
• Marrus N. et al. (2014) Lack of effect of risperidone on core autistic symptoms: data from a longitudinal study. Journal of Child and Adolescent Psychopharmacology. 24(9), Read Abstract (New Window)
  
  
• Martin A. et al. (2004) Weight and leptin changes among risperidone-treated youths with autism: 6-month prospective data. American Journal of Psychiatry. 161(6), Read Abstract (New Window) Read Full (New Window)
  
  
• Masi G. et al. (2001) Open trial of risperidone in 24 young children with pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry. 40(10), Read Abstract (New Window)
  
  
• Masi G. et al. (2003) A 3-year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone. Journal of Clinical Psychiatry. 64(9), Read Abstract (New Window)
  
  
• McCracken J. T. et al. (2002) Risperidone in children with autism and serious behavioral problems. New England Journal of Medicine. 347(5), Read Abstract (New Window) Read Full (New Window)
  
  
• McDougle C. J. et al. (1998) A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. Archives of General Psychiatry. 55(7), Read Abstract (New Window) Read Full (New Window)
  
  
• McDougle C. J. et al. (2005) Risperidone for the core symptom domains of autism: results from the study by the Autism Network of the Research Units on Pediatric Psychopharmacology. American Journal of Psychiatry. 162(6), Read Abstract (New Window) Read Full (New Window)
  
  
• McDougle C. J. et al. (1997) Risperidone treatment of children and adolescents with pervasive developmental disorders: A prospective, open-label study. Journal of the American Academy of Child and Adolescent Psychiatry. 36 Read Abstract (New Window)
  
  
• Miral S. et al. (2008) Risperidone versus haloperidol in children and adolescents with AD: a randomized, controlled, double-blind trial. European Child and Adolescent Psychiatry. 17(1), Read Abstract (New Window)
  
  
• Mukaddes N. M., Abali O., Gurkan K. (2004) Short-term efficacy and safety of risperidone in young children with autistic disorder (AD). World Journal of Bilogical Psychiatry. 5(4), Read Abstract (New Window)
  
  
• Nagaraj R., Singhi P., Malhi P. (2006) Risperidone in children with autism: randomized, placebo-controlled, double-blind study. Journal of Child Neurology. 21(6), Read Abstract (New Window)
  
  
• Nicolson R., Awad G. A., Sloman L. (1998) An open trial of risperidone in young autistic children. Journal of the American Academy of Child and Adolescent Psychiatry. 37(4), Read Abstract (New Window)
  
  
• Nikoo M., Radnia H., Farokhnia M. (2015) N-acetylcysteine as an adjunctive therapy to risperidone for treatment of irritability in autism: a randomized, double-blind, placebo-controlled clinical trial of efficacy and safety. Clinical Neuropharmacology. 38(1), Read Abstract (New Window)
  
  
• Nikvarz N. N. et al. (2017) Comparing efficacy and side effects of memantine vs. risperidone in the treatment of autistic disorder. Pharmacopsychiatry. 50(1), Read Abstract (New Window)
  
  
• Pandina G. J. et al. (2006) Risperidone improves behavioral symptoms in children with autism. in a randomized, double-blind, placebo-controlled trial. Journal of Autism and Developmental Disorders. 37(2), Read Abstract (New Window)
  
  
• Rausch J. et al. (2005) Open-label risperidone for Asperger's disorder: negative symptom spectrum response. Journal of Clinical Psychiatry. 66(12), Read Abstract (New Window)
  
  
• Research Units on Pediatric Psychopharmacology (RUPP) Autism Network (2005) Risperidone treatment of autistic disorder: longer-term benefits and blinded discontinuation after 6 months. American Journal of Psychiatry. 162(7), Read Abstract (New Window) Read Full (New Window)
  
  
• Scahill L. et al. (2012) Effects of risperidone and parent training on adaptive functioning in children with pervasive developmental disorders and serious behavioral problems. Journal of the American Academy of Child and Adolescent Psychiatry. 51(2), Read Abstract (New Window)
  
  
• Scahill L. et al. (2016) Weight gain and metabolic consequences of risperidone in young children with autism spectrum disorder. Journal of the American Academy of Child and Adolescent Psychiatry. 55(5), Read Abstract (New Window)
  
  
• Shea S. et al. (2004) Risperidone in the treatment of disruptive behavioral symptoms in children with autistic and other pervasive developmental disorders. Pediatrics. 114(5), Read Abstract (New Window) Read Full (New Window)
  
  
• Troost P. et al. (2005) Long-term effects of risperidone in children with autism spectrum disorders: a placebo discontinuation study. Journal of the American Academy of Child and Adolescent Psychiatry. 44(11), Read Abstract (New Window)
  
  
• Tyrer P. et al. (2008) Risperidone, haloperidol, and placebo in the treatment of aggressive challenging behaviour in patients with intellectual disability: a randomised controlled trial. Lancet. 371(9606), Read Abstract (New Window)
  
  
• Vercellino F. et al. (2001) Open-label risperidone treatment of 6 children and adolescents with autism Canadian Journal of Psychiatry. 46(6),
  
  
• Vitiello B. et al. (2005) Assessment of the integrity of study blindness in a pediatric clinical trial of risperidone. Journal of Clinical Psychopharmacology. 25(6), Read Abstract (New Window)
  
  
• Williams S. K. et al. (2006) Risperidone and adaptive behavior in children with autism. Journal of the American Academy of Child and Adolescent Psychiatry. 45(4), Read Abstract (New Window) Read Full (New Window)
  
  
• Zuddas A. et al. (2000) Long-term risperidone for pervasive developmental disorder: efficacy, tolerability, and discontinuation. Journal of Child and Adolescent Psychopharmacology. 10(2), Read Abstract (New Window)
  
  

Updated

17 Jun 2022

Last Review

01 Jul 2018

Next Review

01 Jul 2024